MSNBIO 2622 - Fall 2015

Mechanisms and Clinical Presentation of Pain Schedule

(MSNBIO 2622, 3 semester hours)

Mondays and Thursdays, 3:30 - 5:00 p.m., 1495 BSTWR (THE NEW SCHEDULE WILL BE AVAILABLE IN NEAR FUTURE)

G.F. Gebhart, Course Director
Phone: 412-383-5911
Location: W1444 BSTWR

DateTopicPresenterReading Assignments

31 August

Course orgaination, pain taxonomy, overview, introductions

G. Gebhart

- Melzack & Wall (1965) - Pain mechanisms: A new theory- E. Perl (2006) - Ideas about pain, a historical view

3 September

Nociceptors (definition, assessment, heterogeneity, characteristics)

G. Gebhart

-Usoskin et al (2015) Unbiased classification of sensory neuron types by ...RNA sequencing.-Djouhri & Lawson (2004) - Ab-fiber nociceptive primary afferent neurons...

7 September

No Class - Labor Day


10 September

Evolution of pain medicine

A. Wasan


14 September

Pain Fellows case reports:

-Abdallah, Rany

-Gupta, Pallavi



17 September

Pain Fellows case reports:

-Patel, Jaymin

-So, Sokpoleak



21 September

Pain Fellows case reports:

-Waheed, Rehan

-Wert, Joshua



24 September

Injury-induced changes in afferent signaling

M. Gold

- Levine (2013) - Pain is the cell   
- Gold & Gebhart (2010) - Nociceptor sensitization in pain pathogenesis

28 September

Dorsal horn - structure and function

R. Koerber

- Todd (2010) - Neuronal circuitry for painprocessing in the dorsal horn

1 October

Injury-induced changes in dorsal horn signaling

R. Koerber

- Todd (2015) - Plasticity of inhibition in the spinal cord
- Kuner (2014) - Synaptic plasticity in pathological pain

5 October

Supraspinal representation of pain

J. Ibinson

- Schweinhardt & Bushnell (2010) - Pain imaging in health and disease

8 October

Itch and Pain

S. Ross

- Ikoma et al (2006) - The neurobiology of itch

12 October

Descending modulatory pathways

G. Gebhart

- Ossipov et al (2010) Central modulation of pain

15 October

Ascending Pathways

R. Seal

- Craig (2003) - Pain mechanisms.

19 October

No Class - Society for Neuroscience Meeting


22 October

Neuropathic pain

M. Gold

- Finnerup et al. (2015) - Lancet Neurol Neup Review
-Gilron (2015) - Neup Review


Distribution of Progress Exam, due back 26 October


26 October

Cancer and peripheral nervous system: pain-inflammation and metastasis

B. Davis

- Bapat et al (2011)Perineural invasion and associated pain in pancreatic cancer
- Raphael et al (2010) Cancer pain
- Peterson et al (2015) Cell Stem Cell

29 October

Perioperative pain management

Q. Liu, Anesthesiology

-Kehlet et al (2006) - Persistent post surg. pain -Risk factors.
-Niraj (2011) - Persistent Post operative pain.

2 November

Growth factors, cytokines, chemokines and pain

K. Albers

- Bannwarth (2015) - Biolog. in treatments of chronic pain.
- Grace et al. (2014) - Pathological pain neuroimmune interface.

5 November

Pain in the aged

D. Weiner, Medicine, Director, Geriatric Med Fellowship

- Weiner et al (2013) - Pain Meds Older Adults.

9 November

Management of chronic low back pain

A. Delitto, Physical Therapy


12 November


M. Schneider, Physical Therapy

- Boomershine (2014) Fibromyalgia.
- Clauw (2014) - Fibromyalgia - latest in diagnosis & care.

16 NovemberVisceral pain (clinical presentation, mechanisms) K. Bielefedt

 - Bielefeldt & Gebhart (2012) Visceral Pain

19 November

Genetic factors predictive of the emergence of chronic pain

P. Dalby, Anesthesiology

- Young (2008) - Genetic basis of pain.
- Max (2008) - Molecular epidemiology.

- Belfer (2010) - Phenotyping & genotyping neuropathic pain.

23 November

Psychosocial assessment and behavioral treatment of chronic pain

C. Greco, Psychiatry

- Jensen (2014) Neuromodulation - chronic pain
- McCracken (2014) Behavioral models pain

26 November

NO CLASS - Thanksgiving


30 November

Pain in Children

C. Yang, Anesthesiology


3 December

Pain and sleep

B. Hasler, Psychiatry

- Finan et al (2013) Sleep and pain

7 December


R. Kaniecki, Director, The Headache Center

- Magon et al (2015) - Migraine thalamus
- Hodkinson et al (2015) - Migraine Primary Somatosensory


Student papers due


10 December

Student presentation


If you have a disability for which you are or may be requesting an accommodation, you are encouraged to contact both the course director and Disability Resources and Services, 216 William Pitt Union, (412) 648-7890/(412) 383-7355 (TTY), as early as possible in the term. DRS will verify your disability and determine reasonable accommodations for this course.

1. Students registered in the course will be asked to select from a list a topic for a paper (10 double spaced pages, not including references, figures or tables). The paper is Due Monday 5pm, 9 April and will constitute - in conjuction with the oral presentation of the topic - about 50% of the course grade. Students will give an oral presentation (20-30 min) of the paper/topic at the end of the semester.

Schedule for Spring 2008
Schedule for Spring 2009
Schedule for Spring 2011
Schedule for Spring 2012
Schedule for Spring 2013
Schedule for Spring 2014